i've had a WP multisite install working on enhance, with no manual changes to the vhost.
using OLS as the webserver though, so not sure how nginx will handle it.
it was a site already working on another panel using apache, copied over into enhance using duplicator pro.
all the extra domains were added to the website as aliasdomains, not additional domains
was done for testing, so all the domains were changed during copying so the live site was unaffected.
the site was already using the plugin domain-mapping by wpmu-dev.
i had to go in to this plugins settings on each subsite and delete the existing mapping and create a new mapping for the changed domain. if migrating a site and keeping the existing domains, i don't think this step would be needed, but can't guarantee that at this point.
only other issue was having to change edit the sites index.php to put the standard content in there.
duplicator had left it essentially blank (just a 'silence is golden' entry in there)
although that may be because i changed the wordpress path during install, as on the live site wordpress was installed into a subdirectory named 'wordpress' in the website root, and i decided to install wordpress directly into the website root folder on enhance.