jgrispa really hard to get mod security configured to work with WordPress. I must have disabled a dozen filters and whitelisted a dozen paths, still run into conflicts, gave up because I figured by the time I could get mod security fully compatible with WordPress I'd probably have disabled 99.9% of it lol
BTW, another common reason that issue happens is because people are using emojis in posts, and their database table collection isn't compatible with storing emojis, gotta upgrade tables from utf8mb3 to utf8mb4.
I sometimes get the error message on very bloated pages too, pages with like +100 blocks on them. I'll just keep clicking save and it eventually goes through 😫