Sorry this one was missed. Yes you can absolutely do this and I've seen many customers doing so. Enhance won't do anything to your container. Since docker is a dependency of appcd, updating appcd might also update docker which in tur might require a restart.
There is currently no way to configure nginx as a reverse proxy with Enhance but you can do it with Apache or LiteSpeed. You can either place the container in the
enhance_network docker network and refer to it with its container name, or you can place it in a separate docker network and use the host IP.