JohnB If your provider uses XCP-ng - they can do a number of different replication options that are very reliable, block-level backups. The Delta and Continuous replications, even Disaster Recovery options available on that platform are essential. They should also be providing further options for mission critical VM.
At this moment, we are out of testing phase into early deployment of Enhance, so, we make sure that all the cluster servers, even the backup nodes, have full disaster recovery copies ready, just in case.
For the Control Panel server, we have that backed up in several locations in DR mode for near instant recovery. I will be able to get more than 2 hours of sleep at night once Enhance releases the replica option mentioned by Adam, above... 😉