Krikke Changing the default WordPress database prefix is a good practice, but it doesn't guarantee complete protection against SQL injection attacks. A determined hacker could still exploit vulnerabilities, even with a custom prefix. It might make their job slightly harder, but it's not a foolproof solution.
Personally, I change the prefix whenever possible during installation, but it's not a top priority if the option isn't available.
If you want to change it after installation with Enhance, you can use a plugin.